Sergel Capsule 20 belongs to the group of medications known as proton pump inhibitors, which helps your stomach produce less acid. Sergel Capsule 20 treats Zollinger-Ellison syndrome, stomach ulcers, and gastroesophageal reflux disease (GERD). (overproduction of acid due to pancreatic tumor).
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Sergel 20 is a medication that lowers the amount of acid produced in the stomach. It is used to treat heartburn, acid reflux, and food pipe issues. It is also employed in the prevention and treatment of stomach ulcers. You should take Sergel 20 as directed by your doctor.
Caution is advised when consuming alcohol with Sergel 20. Please consult your doctor.
Sergel 20 may be unsafe to use during pregnancy. Although there are limited studies on humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing them to you. Please consult your doctor.
Sergel 20 is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
It is not known whether Sergel 20 alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
Sergel 20 is safe to use in patients with kidney disease. No dose adjustment of Sergel 20 is recommended. However, inform your doctor if you have any kidney disease.
Sergel 20 should be used with caution in patients with severe liver disease. A dose adjustment of Sergel 20 may be needed. Please consult your doctor.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Sergel 20 is to be taken empty stomach.
Sergel 20 is a proton pump inhibitor (PPI). It works by reducing the amount of acid in the stomach which helps in the relief of acid-related indigestion and heartburn.
If you miss a dose of Sergel 20, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
The most common side effects associated with Esomeprazole include
There is no difference in the types of associated adverse events seen after maintenance treatment for up to 12 months vs short-term treatment.
Sergel 20 is used to treat chronic heartburn and other symptoms associated with GERD.
Sergel is a proton pump inhibitor that reduces stomach acid production by specifically inhibiting the H+/K+-ATPase in the gastric parietal cell. Esomeprazole (S-isomer of omeprazole) is the first proton pump inhibitor with a single optical isomer that outperforms racemic proton pump inhibitors in acid control.
For absorption, Sergel capsules contain an enteric-coated pellet formulation of esomeprazole magnesium. Peak plasma levels (Cmax) occur approximately 1.5 hours after oral administration (Tmax). When the dose is increased, the Cmax rises proportionally, and the area under the plasma concentration-time curve (AUC) rises three times from 20 to 40 mg. With repeated once-daily administration, systemic bioavailability is around 90%, compared to 64% with a single dose.
In comparison to fasting conditions, the AUC after a single dose of esomeprazole is reduced by 33-53 percent after food ingestion. Esomeprazole should be taken at least one hour before meals.
In 97 percent of cases, Sergel is linked to plasma proteins. Plasma protein binding is constant over a concentration range of 2 20 mmol/L. At a steady state, the apparent volume of distribution in healthy individuals is around 16 L.
Esomeprazole is extensively metabolized in the liver by the cytochrome P450 (CYP) enzyme system. Metabolites of esomeprazole have no anti-secretory activity. The majority of esomeprazole metabolism is carried out by the CYP2C19 isoenzyme, which generates the hydroxy and desmethyl metabolites. The rest is reliant on CYP3A4, which generates the sulphone metabolite.
Sergel 20 is successful at treating Zollinger-Ellison syndrome, gastroesophageal reflux disease, and erosive esophagitis (inflammation of the food pipe). The proton pump gate is permanently blocked by Sergel 20. (which secretes stomach acid). All age groups, including specific populations like the elderly, pregnant, breastfeeding moms, and renal, and liver disease patients, can receive a prescription for it. For these populations, dose adjustments are typically not necessary.
CYP2C19 and CYP3A4 substantially metabolize esomeprazole in the liver. Esomeprazole is unlikely to inhibit CYPs 1A2, 2A6, 2C9, 2D6, 2E1, and 3A4, according to in vitro and in vivo investigations. There should be no clinically significant interactions with medicines processed by these CYP enzymes. Esomeprazole has no clinically significant interactions with phenytoin, warfarin, quinidine, clarithromycin, or amoxicillin, according to drug interaction studies.
Sergel may interact with the main Esomeprazole metabolizing enzyme, CYP2C19. Co-administration of Esomeprazole 30 mg with diazepam, a CYP2C19 substrate, resulted in a 45 percent reduction in diazepam clearance. Increased diazepam plasma levels have been reported 12 hours after treatment and beyond. Esomeprazole works by inhibiting stomach acid output. As a result, Esomeprazole may impair medication absorption in cases where stomach pH is a key driver of bioavailability (e.g., ketoconazole, iron salts, and digoxin).
Co-administration of oral contraceptives, diazepam, phenytoin, or quinidine does not appear to alter Esomeprazole's pharmacokinetic profile.
Combination Therapy with Clarithromycin: Co-administration of esomeprazole, clarithromycin, and amoxicillin has resulted in increases in esomeprazole and 14-hydroxy clarithromycin plasma levels.
Esomeprazole is not recommended for those who have a history of hypersensitivity to any of the formulations.
In pregnant women, there are no appropriate and well-controlled trials. Teratogenic effects have not been discovered in animal investigations. Esomeprazole excretion in milk has not been examined. If the use of esomeprazole is deemed necessary, breastfeeding should be stopped.
In general, symptomatic response to esomeprazole treatment does not rule out the presence of stomach cancer.
Sergel pills should be taken at least one hour before meals, according to the manufacturer's instructions. For patients who have trouble swallowing capsules, put one spoonful of applesauce in an empty bowl, open the Esomeprazole capsules, and carefully pour the pellets within the capsule into the applesauce. The pellets should be combined with the applesauce and quickly eaten. The applesauce used should be cold and mushy enough to be eaten without chewing. It is not recommended that the pellets be eaten or crushed. The pellet/applesauce combination should not be kept in the refrigerator for later usage. While using esomeprazole, you may use antacids.
Store in a dry location at a temperature not exceeding 30°C. Keep out of direct sunlight and dampness. Keep out of children's reach.
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